Detalhe da pesquisa
1.
Reshaping endoplasmic reticulum quality control through the unfolded protein response.
Mol Cell
; 82(8): 1477-1491, 2022 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35452616
2.
PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid.
EMBO J
; 42(15): e113908, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306086
3.
Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.
Mol Cell
; 75(5): 1073-1085.e6, 2019 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31327635
4.
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Proc Natl Acad Sci U S A
; 120(20): e2300763120, 2023 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37155889
5.
ATF6 protects against protein misfolding during cardiac hypertrophy.
J Mol Cell Cardiol
; 189: 12-24, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38401179
6.
Mitochondria and Endoplasmic Reticulum Stress in Retinal Organoids from Patients with Vision Loss.
Am J Pathol
; 193(11): 1721-1739, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36535406
7.
ATF6 is essential for human cone photoreceptor development.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34561305
8.
Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.
J Biol Chem
; 298(3): 101694, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35143841
9.
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.
Bioorg Med Chem Lett
; 89: 129306, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37116763
10.
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.
Nat Chem Biol
; 16(10): 1052-1061, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690944
11.
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.
Mol Ther
; 29(5): 1862-1882, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33545358
12.
Small molecule strategies to harness the unfolded protein response: where do we go from here?
J Biol Chem
; 295(46): 15692-15711, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32887796
13.
The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.
EMBO J
; 36(15): 2296-2309, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28655754
14.
Starting at the beginning: endoplasmic reticulum proteostasis and systemic amyloid disease.
Biochem J
; 477(9): 1721-1732, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32412081
15.
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates.
Acta Neuropathol
; 140(5): 737-764, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32642868
16.
SnapShot: The unfolded protein response.
Cell
; 140(4): 590-590.e2, 2010 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20178750
17.
Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts.
Int J Mol Sci
; 21(16)2020 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32796510
18.
Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.
EMBO J
; 34(1): 4-19, 2015 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361606
19.
Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.
Biochemistry
; 57(13): 2035-2043, 2018 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29521097
20.
Lining up for quality control: linear ubiquitin and proteotoxicity.
EMBO J
; 38(9)2019 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30975687